Silly question. An ESFJ raised by one or more transgender parents will have no issue. An ESFJ from a highly religious background may have significant issue. One can assume that an ESFJ's opinion on this issue is based on two factors.
A. Can the ESFJ sympathize or empathize with an individual who is transgender, or do they have a transgender individual in their life with whom they have an emotional connection. (Fe)
B. The other, and perhaps most important in answer to this question, is the way that the ESFJ was raised. What did their parents or environment teach them about transgender individuals? Were they taught that it was normal? Immoral? (Fe-Si)
Thusly ESFJs in general cannot be assessed for an opinion on any similar issue based on type, but only by individual on a case by case basis. I'm sure someone's already said this, but I'm on my phone, so I haven't bothered reading through the entire thread.