During the luteal phase of the menstrual cycle, where the lining of the uterus is being broken down, progesterone is higher in women, and there is a coorelation between higher progesterone in women, and lower serotonin. This does not happen to such a great extent in some women as it does others. Some one them may feel little to no symptoms from the decreased serotonin (dysphoria) - but others may have it at the other extreme of the scale, and feel very dysphoric. This is why the rage and depression.. or, PMS. But, in those who have such extreme cases its called PMDD. Now to answer your question, yes, I happen to be one of the unfortunate women who has PMDD. My serotonin is depleted during my luteal phase. The thing is, I know that its the culprit.. I am so familiar with it happening that I can feel that things in my brain are different the first day of each luteal phase. I compensate by not putting myself in situations that will annoy me. I am basically out of commission for a week a month, before menstruation actually begins. I can feel the first signs of serotonin stabilizing in my brain again a few days before I start to menstruate.