I've come to the realization that I'm highly sensitive, because of my physical reactions to foods, sounds, conflict (or just high energy/high commotion settings) throughout my life.
Physical pain, stress, loud noises, loud talking, crowded areas, people who get too close, smells (strong or mild), changes in temperature, irritatingly bright lights and anything that triggers nostalgia bring out strong physical reactions (and significant changes in mood). Humid/overcast days bring about a tension headache the day before and the day of.
As far as gender-specific ailments, it's a hell-bound Odyssey. I withdraw into myself and remain in a quiet room until I can regain control. Any emotional reaction has a thought component, which can set up a particular expectation. However, change what you focus on and the result can be quite different.
All in all, I don't see hyper-sensitivity as a weakness; on the contrary, it's just that one's system is closely tied to the world and the ever changing energies of the surrounding environment.