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Unipolar major depression, the fucking terrible condition characterized by extended episodes of low mood, apathetic responses to your environment, diminished energy, inability to ascertain feelings, poor sleep patterns, feelings of worthlessness, suicidal ideation, loss of the capacity to experience pleasure, etc...Does depression become an all encompassing burden to bear, or is it the doorway to creative insight and life fulfilling meaning?

It depends, if you let consume you then it will destroy you. But I really do believe it can be an opportunity.
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