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Tolerance of drugs has a lot to do with intoversion/extroversion. Introverts are a lot more succeptable to the effects of brain-altering drugs.

When I drink caffiene I'm either in an entergetic mood, or I have major fatigue.
When I smoke, one hit and I'm gone. I just had the worst high of my life last weekend. I've never been so paranoid. I'd bet partly because I don't smoke too often.

Of course it depends on your frequency of use and your tolerance resulting from that.
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